DefinitionThis section has been translated automatically.
Antibiotics produced by Streptomyces species. They are related to macrolide antibiotics in terms of their spectrum and mechanism of action. The only representative of the lincosamides is clindamycin, a semi-synthetic analog of lincomycin. Clindamycin is a weak base that binds to the 50S subunit of bacterial ribosomes and inhibits protein synthesis.
Note: Lincomycin is no longer used today.
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of protein synthesis at the 50S subunit of the bacterial ribosome.
Note(s)This section has been translated automatically.
Clindamycin is the most effective antibiotic against anaerobes. It is also excellent against staphylococci and good against streptococci and pneumococci.
LiteratureThis section has been translated automatically.
Graefe KH et al (2016) Antibacterial agents. In: Graefe KH et al (Eds) Pharmacology and Toxicology. Georg Thieme Publisher Stuttgart S. 583-584
Prof. Dr. med. Peter Altmeyer